The analysis points overwhelmingly towards an away victory for Brentford. The primary factor is the significant disparity between a Premier League team and a League Two side. Brentford's recent victories against teams like West Ham and Manchester United demonstrate a level of performance that Grimsby will find exceptionally difficult to contain. Although Grimsby has had some positive results in their own division, including a resounding 7-1 win, the step up in opposition is immense. Historically, the head-to-head record is somewhat dated, with the last meeting in 2009, making it largely irrelevant to the current squads. Brentford does have some injuries to contend with, but their squad depth is more than capable of compensating in a fixture like this. From a tactical perspective, Brentford is expected to control the game from the outset, dominating possession and creating numerous chances. Grimsby's best hope will be to defend resolutely and look to capitalize on a rare counter-attack or set-piece. However, it is more likely that Brentford's quality will shine through, leading to a controlled victory. The prediction of a 2-0 scoreline reflects Brentford's superiority while acknowledging that cup ties can sometimes see the bigger teams do just enough to secure the win without an avalanche of goals.